Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 30th Annual American Dentistry Congress Orlando | Florida | USA.

Day 2 :

Conference Series American Dentistry 2019 International Conference Keynote Speaker Kamran Awan photo
Biography:

Kamran Habib Awan is a renowned international speaker in the field of oral medicine and diagnosis. He completed his bachelor’s in dental surgery with first division from Karachi University in 1997. Dr. Awan was awarded his Ph.D. in oral medicine from Kings College, London in 2011. His study was the first ever to evaluate the number of diagnostic methods in comparison to surgical biopsy (gold standard). He serves as an advisory board member for several reputed journals. He also has numerous publications to his name. His research interests include oral cancer and diagnosis. Dr. Awan currently serves as an associate professor at the Roseman University of Health Sciences, Utah, United States.

Abstract:

Human papillomavirus (HPV) has for some time been suggested to be involved in the carcinogenesis of oropharyngeal cancer. The HPV is a small, circular double-stranded DNA virus that was first identified in 1949. Up till now, over 100 different HPV types have been identified. The HPV subtypes are divided into high-risk and low-risk HPV based on their malignant potential. Approximately, 15 high-risk subtypes are known but only HPV subtypes 16, 18, 31, 33, and 35 have been identified playing a role in the development of oropharyngeal head and neck cancer. The HPV 16 is the most common type detected in oropharyngeal cancer accounting for 90 to 95% of the HPV-positive tumors. The International Agency for Research on Cancer (IARC) now recognizes HPV as a risk factor for oropharyngeal cancer and accumulating molecular and epidemiological data now show that high-risk types of HPV are responsible for a subset of oropharyngeal cancer. Majority of the HPV-positive oropharyngeal cancers lack association with the traditional risk factors, such as tobacco and alcohol. Alike HPV-associated cervical cancers, HPV-positive oropharyngeal cancers are also sexually transmitted. It is assumed that HPV infection precedes the development of HPV-positive head and neck cancers, and the presence of high-risk HPV infection on the oral mucosa and seropositivity increases the risk of development of head and neck cancers. Therefore, risk factors for oral HPV infection are likely to be risk factors for HPV-positive head and neck cancers.

 

Keynote Forum

Kariem M Elhelow

King Abdullah Medical City, Saudi Arabia

Keynote: Dental implants in pediatric jaws. Any new solutions for old problems?
Conference Series American Dentistry 2019 International Conference Keynote Speaker Kariem M Elhelow photo
Biography:

Kariem M Elhelow BDS, MS, Ph.D., is working a Consultant of Implant and Maxillofacial Prosthodontics, in King Abdullah Medical City, Makkah, Saudi Arabia. He worked as a prosthodontist in Alexandria University as well as Salametek Dental Centers. Dr. Elhelow received his BDS, and MS from Alexandria University, and his Ph.D. from Cairo University, Egypt. He is also a fellow of the ICOI. He is an author and international public speaker lecturing on implant, maxillofacial prosthodontics, and digital dentistry.

Abstract:

Traumatic tooth loss is a common incident in active children. The mean prevalence of congenitally missing teeth was reported to be 6.53% ± 3.33%; and therefore, they make up the vastness of the developmental anomaly of the human dentition. While researches are extensively addressing every aspect related to implants in adults, a paucity of equivalent articles are tackling dental implants in growing children and adolescents. It is widely accepted that dental implants should not be installed in growing children. The presentation will elaborate on how far this notion holds true today together with the clinical encounters anticipated. Knowledge about the behavior of dental implants in growing jaws coupled with correct patient selection and clinical guidelines are paving the way to more predictable functional and esthetic outcomes. The purpose of this article is to draw a roadmap to decision making addressing the do’s and don’ts when considering dental implants in growing children.

Conclusion: Implant rehabilitation is possible in young jaws. Growth assessment together with multidisciplinary management is crucial to avoid functional and esthetic failures.

Recommendations: Aside from the points highlighted in the presentation, it is recommended that Implant practitioners become oriented with growth assessment methods; a skill that is frequently overlooked.

Keynote Forum

Kariem M Elhelow

King Abdullah Medical City, Saudi Arabia

Keynote: Dental implants in pediatric jaws. Any new solutions for old problems?

Time : 11:00-11:45

Conference Series American Dentistry 2019 International Conference Keynote Speaker Kariem M Elhelow photo
Biography:

Kariem M Elhelow BDS, MS, Ph.D., is working a Consultant of Implant and Maxillofacial Prosthodontics, in King Abdullah Medical City, Makkah, Saudi Arabia. He worked as a prosthodontist in Alexandria University as well as Salametek Dental Centers. Dr. Elhelow received his BDS, and MS from Alexandria University, and his Ph.D. from Cairo University, Egypt. He is also a fellow of the ICOI. He is an author and international public speaker lecturing on implant, maxillofacial prosthodontics, and digital dentistry.

Abstract:

Traumatic tooth loss is a common incident in active children. The mean prevalence of congenitally missing teeth was reported to be 6.53% ± 3.33%; and therefore, they make up the vastness of the developmental anomaly of the human dentition. While researches are extensively addressing every aspect related to implants in adults, a paucity of equivalent articles are tackling dental implants in growing children and adolescents. It is widely accepted that dental implants should not be installed in growing children. The presentation will elaborate on how far this notion holds true today together with the clinical encounters anticipated. Knowledge about the behavior of dental implants in growing jaws coupled with correct patient selection and clinical guidelines are paving the way to more predictable functional and esthetic outcomes. The purpose of this article is to draw a roadmap to decision making addressing the do’s and don’ts when considering dental implants in growing children.

Conclusion: Implant rehabilitation is possible in young jaws. Growth assessment together with multidisciplinary management is crucial to avoid functional and esthetic failures.

Recommendations: Aside from the points highlighted in the presentation, it is recommended that Implant practitioners become oriented with growth assessment methods; a skill that is frequently overlooked.

  • Orthodontics | Oral Medicine | Oral and Maxillofacial Surgery | Diagnosis and Prevention of Oral Disease | Prosthodontics | Oral and Dental Health
Location: International A
Speaker

Chair

Jaana Hannele Sippus

Laseredu Ltd, Finland

Speaker

Co-Chair

Kariem M Elhelow

King Abdullah Medical City, Saudi Arabia

Speaker
Biography:

Abstract:

Purpose: The purpose of these studies was to compare the esthetic outcome and the infiltration capacity of three resin composite sealers: Biscover LV (Bisco Dental), Optiguard (Kerr) and Permaseal (Ultradent) to ICON (DMG, America) when treating artificial initial caries lesions with resin infiltration.

Methods: A panel of artificial initial caries lesion were created on buccal and lingual surfaces of 75 extracted human molars. Specimens were randomly assigned to 5 groups: ICON, Biscover, Optiguard, Permaseal and a control group (no infiltration). Teeth were hemi sectioned yielding two halves, each with a panel of artificial caries lesion. Lesions on one hemi section were used to assess the esthetic improvement following caries lesion infiltration with the 4 resins based on photographs evaluated with a 100-mm visual analogue scale (VAS) by 17 raters. Lesions on opposite hemi section were used to measure the resin infiltration area percentage (IA%) and the resin infiltration depth percentage (ID%) visualized by the confocal laser scanning microscope (CLSM).

Results: The mean IA% and ID% values were significantly higher for ICON, intermediate for Optibond and Permaseal and significantly lower for Biscover. ICON, Optiguard and Permaseal yielded significantly greater average VAS scores compared to Biscover. A moderately large positive correlation was noticed between the average VAS scores and the infiltration measures.

Conclusion: All the resin sealers Biscover, Optiguard and Permaseal infiltrated the artificial initial caries lesions, however ICON resulted in the deepest infiltration depth and largest infiltration area. The esthetic outcome following artificial initial caries lesion resin infiltration with Optiguard and Permaseal was similar to ICON and thus might be adequately used in caries resin infiltration.

Speaker
Biography:

Abstract:

Objectives: The aim of this in-vitro study was to compare the shear bond strength (SBS) and to evaluate the adhesive remnant index (ARI) of stainless-steel orthodontic brackets bonded with two different orthodontic adhesives (Transbond XT and Bracepaste); decalcification at the base of the brackets were also recorded.

Materials and Methods: A total of 16 surfaces (buccal and lingual) of 8 extracted human molars were randomly divided into two groups. The shear bond strength was performed by using the Universal Testing Machine (Instron 5566 Test Bench) and the results were recorded in megapascals (MPa). The Adhesive Remnant Index (ARI) scores were determined with the LEICA MZ APO stereomicroscope. Additionally, the element analysis for the base of orthodontic brackets was done by using the scanning electron microscope (SEM) to detect the decalcification.

Results: The mean SBSs of Bracepaste (20.67 ± 5.76) and Transbond XT (22.29 ± 5.02) showed a clinically acceptable SBS values and there was no statistically significant difference according to one-way analysis of variance. As well as the ARI scores were not statistically significant difference in both groups based on Chi-square test. The SEM-EDS of elements analysis showed that Calcium and Phosphate were detected when the debonding take place at the enamel-adhesive interface.

Conclusion: There was no statistically significant difference between Transbond XT and Bracepaste, and it was concluded that both types have a sufficient bond strength to be used for bonding the orthodontic brackets.

 

Speaker
Biography:

The purpose of this presentation is to carefully analyze the findings to date regarding a potential link between periodontitis and carcinogenesis; evaluate, critically review and explore the variety of potential study confounders and study criteria differences which suppress the accuracy and validity of the relationship claims being made; gain an appreciation of the biological plausibility of mechanisms which could be under pinning the relationship between the two diseases; and finally to conclude whether the current level, findings and quality of research is accurate in supporting the existence of the periodontitis cancer link. I will assess the potential link between periodontitis and several cancerous tumors types, and analyze the evidence regarding the biological plausibility for the potential association between periodontitis and cancer. The strongest association is present between periodontitis and oral cancer since each of the three studies looked into show a statistical link between both diseases. The international burden of cancer has risen every year, a trend that has been paralleled by the increase in periodontitis cases. Research undertaken by GLOBOCAN (2012) states there were7.6 million global cancer cases in 2008, and in 2012 there were14.1 million global cancer cases, an increase of 84%. Although there is a lack of recent statistical data related to periodontitis cases, between the years 1997 and 2005, there was an increase of 27% of adults aged between 35 and 44 who had Periodontal pocket depths greater or equal to 4 millimeters (Dye, 2012).

 

Abstract:

Kishan has published in several internationally renowned dental magazines, as well as having recently been accepted into his first international peer reviewed journal, the ‘Journal of Dental Health, Oral Disorders and Therapy’. He has presented work at 2 national conferences and also 2 international conferences in Sharjah and Dubai, UAE, and has also lectured alongside PhD level students in the past for the London Materials’ Society on the topic of MI dentistry. He was recently asked to give interviews for the British Dental Journal and Dental Town. Kishan is also on the honorary editorial board for Dental Town UK. Over the past two years, he has been working on a publication with Dr. Mandeep Ghuman entitled’ Periodontitis and Cancer: Is there a link?’ Aside from dentistry, he is a choreographer and lead dancer for the London based Shri Academy of Dance, as well as being a senior partner. He loves dancing and acting and has co‐choreographed for the Diwali Show for two years running!

 

Speaker
Biography:

Dana Jafarpur is a sixth-year dental student at Shiraz University of Medical Sciences. Next semester she will be graduating summa cum laude from Shiraz Dental School and has written a book in forensic dentistry and published 5 papers during her undergraduate studies.

Abstract:

Objectives: To evaluate the effect of different Nano filled resin coatings on the staining susceptibility of glass ionomer restoratives after immersion in three food simulating solutions (FSS).

Methods: Five encapsulated glass-ionomer restoratives (Riva light-cure (SDI), Riva self-cure (SDI), Fuji II LC (GC), Fuji Bulk (GC) and Equia Forte Fil (GC)) and two Nano filled coatings (EQUIA Coat (GC) and G-Coat plus (GC)) were employed. All specimens were immersed in distilled water for 24 h and then subjected to a color measurement with a spectrophotometer. Then the samples were divided into three subgroups and immersed for another one week in lactic acid (0.1mol/L), coffee, and distilled water (control) respectively. The differences in the lightness and chromaticity values (ΔL, Δa, Δb) were determined and the total color change (ΔE) was calculated using the formula: ΔEn= [( ΔLn)2+( Δan)2 + ( Δbn)2]1/2

Results: Three-Way ANOVA showed a significant interaction effect between materials, coatings and solutions for the color change values. Therefore, one-way ANOVA was used to compare different variables between the materials. Color change values (ΔE) varied depending on the material and solution. G-Coat Plus exhibited lower color change values compared to the EQUIA-coated and the uncoated groups. The effect of immersion in FSS on color change values among materials varied depending on the type of coating.

 

Speaker
Biography:

Gustavo Ferreira is a specialist in Sports Dentistry. He is the first President of the Brazilian Academy of Sports Dentistry (ABROE). He currently serves as the Partner- Director of Odontofitness, Botafogo Football Club.

Abstract:

The Sports Dentistry is an area of practice that includes theoretical and practical segments of Dentistry, aiming to investigate, prevent, treat and rehabilitate, understanding the influence of diseases of the oral cavity on the performance of professional and amateur athletes, with the purpose of improving athletic performance and prevent injuries, taking into account the physiological particularities of athletes, the modality they practice and the rules of sport. Technical-scientific knowledge regarding the sporting modality and the physiology of the exercise are of singular importance since both can influence differently in the process of development of alterations or injuries, as well as in the recovery process. Diagnosing and healing all factors that cause a decrease in the physical and psychological performance of the athlete, performing all the necessary procedures, so that the athlete has a standard of excellence when it comes to oral health. Sports dentist care includes: Doping; types of dental materials; dental erosion (isotonic consumption); adequate breathing; body posture (occlusion); facial trauma; dental trauma; mouthguard; periodontitis; follow clinical protocols; oral cancer; dental esthetic and dental disturbances in sleep.

Speaker
Biography:

Richard Miron is currently an Adjunct Visiting Faculty in the Department of Periodontology in Bern, Switzerland where he completed his PhD studies since 2009. He has currently published over 150 peer-reviewed articles and lectures internationally on many topics relating to growth factors, bone biomaterials, and guided bone regeneration. He has recently been awarded many recent international prizes in dentistry and is widely considered as one of the top contributors to implant dentistry having won the ITI Andre Schroeder Prize in 2016, the IADR Young Investigator of the Year in the field of Implant Dentistry in 2015, and the American Academy of Implant Dentistry (AAID) Young Investigator grant award in 2014. He and Dr. Joseph Choukroun have recently edited the first textbook on PRF titled: “Platelet Rich Fibrin in Regenerative Dentistry: From Biological Background to Clinical Indications.

Abstract:

The use of platelet concentrates has had a long history of use in various fields of medicine as an autologous source of growth factors fabricated utilizing centrifugation of blood under various conditions. While platelet-rich plasma (PRP) was proposed as a first-generation platelet concentrate over 3 decades ago, over the past 10 years, platelet rich fibrin (PRF) has seen a steady increase in utilization for a variety of medical procedures due to its lack of anti-coagulation factors favoring fibrin clot formation and faster wound healing. More recently, further research has demonstrated that shorter and slower centrifugation spin cycles (‘the low-speed concept’ now termed advanced-PRF, A-PRF+) additionally favors wound healing by incorporating higher populations of white blood cells and progenitor cells within the PRF fibrin matrix leading to higher growth factor release within the local microenvironment. Parallel to these findings, the development of a liquid injectable PRF (i-PRF) provides a new formulation of liquid PRF without using anti-coagulation factors that may specifically be combined with currently available bone biomaterials favoring particle stability, angiogenesis and tissue integration. This course aims to highlight the recent advancements made with respect to the newest formulations of platelet concentrates and systematically presents when, where and why specific platelet concentrates may be utilized to further speed wound healing and tissue regeneration for various clinical indications faced in routine daily dental practice.

 

Miguel Monteiro de Carvalho Neto

University of Rio de Janeiro State, France

Title: Maximizing aesthetics on single implants
Speaker
Biography:

Miguel Monteiro de Carvalho Neto is now working as an invited professor at Universidade do Estado do Rio de Janeiro (UERJ). He is also a Professor of French Implantology Association. Paris-France (afopi.com).

Abstract:

The beauty in implant dentistry is that every case is an individual challenge. An ideal implant treatment uses procedures, techniques, materials, and technologies that lead fast and on the shortest way to a maximally aesthetic result. The main goal is to achieve osseointegration and aesthetics in order to get long-term stability. For this, we need to obtain both, bone formation and gum thickness, as any failure in one of the 2 factors, will induce the loss of the second factor. The purpose of this presentation is to show participants the tissue stabilization factors and to demonstrate how to achieve the planned results at a single tooth replacement.

Speaker
Biography:

Ehsan Iranmanesh is serving as an assistant professor at Kerman Medical University in Iran. He has several publications on dentistry.

Abstract:

Since the concept of Osseointegration was introduced by Brånemark et al, modern dental implants have been considered a safe and reliable option for replacing missing teeth. By placing dental implants abutment directly in in bone, considering different problems regarding its rejection, if every step is done by standard method the implant will be osseointegrated into the alveolar bone. Osseointegration depends on a multiple of factors such as implant material, surgical technique etc. The implant material mostly includes titanium and its alloys (mostly Titanium alloys Ti6Al4V) zirconia or even fiber-reinforced composite (FRC) which can be a potential material in the near future. For past few decades titanium and its alloys have been the material of choice for dental implant’s abutment. However, titanium has been shown to exhibit a variety of problems. Because of the high modulus of elasticity of the titanium alloys, dental implants made from the material can cause stress-shielding which may lead to periodontal bone loss. Moreover, few cases has been reported with induction of hypersensitivity to the titanium used as implant’s abutment also other problems such as wear debris and ion leakage can also be of concern with titanium dental implants. There is various factor concerning the success or failure of a dental implant by the manner in which stresses are transferred to the surrounding bone. Load transfer from implants to surrounding bone depends on the type of loading, the bone-implant interface, the quantity and quality of the surrounding bone and etc. Finite element analysis (FEA) allows researchers to predict stress distribution in the contact area of the implants with cortical bone and around the implants in trabecular bone. The high-performance biomaterial PEEK (polyether ether ketone) has been applied as implant material in many fields of medicine since the 1990ies. Due to its excellent properties, a high stability and elasticity (elastic modulus: 3-4 GPa), low density (1,32 g/cm3) and insolubility its application have been boosted in the field of dentistry as for the manufacturing of prosthetic reconstructions. Its elastic modulus, similarly, to that of cortical bone, it plays an important role as viable alternative to conventional implant materials such as titanium. This reduces the risk of stress shielding around the implant and makes it suitable for use even in orthopedic procedures and spinal surgery. The stable chemical structure of PEEK makes it extremely unreactive and inherently resistant to chemical and thermal degradation. The inertness of the polymer also explains its biocompatibility, which has been shown both in vitro and in vivo. In this review article we inspect the probable advantages of using the PEEK as a stress shielding material in dental implant’s abutment.

  • Periodontics and Oral Hygiene | Restorative Dentistry and Endodontic | Cosmetic Dentistry | Oral Oncology | Dental Public Health | Radiology
Location: International A
Speaker

Chair

Jason Post

MBS Secure, USA

Speaker

Co-Chair

Kamran Awan

Roseman University, USA

Session Introduction

Dora Zs Nagy

Semmelweis University, Hungary

Title: Caries risk assessment in children between 6-18 in Budapest, Hungary
Speaker
Biography:

Dora Zsofia Nagy graduated from Semmelweis University, Budapest, Hungary in 2014. Since then she has been working at the Department of Paediatric Dentistry and Orthodontics at Semmelweis University. She is a specialist in paediatric dentistry and currently enrolled in the orthodontic residency programme. Besides the daily clinical practice, she has been involved in scientific research projects at the department and in the training of undergraduate students in the Hungarian, English and German speaking dentistry programmes.

Abstract:

Materials and Methods: Dental caries has been a major public health problem for many years in Hungary and still continues to be, affecting in many ways normal growth and development as well as social adaptation of children. A research on caries risk assessment was conducted at the Department of Paediatric Dentistry and Orthodontics at Semmelweis University with 116 children aged 6-18 (mean age: 10, 4). Based on the clinical dental status evaluation the prevalence of dental caries, DMFT, def-t, DF/df-T/t score, and Significant Caries Index (SiC) were calculated. For caries risk assessment the questionnaire of the American Dental Association was filled in by the patients’ caretaker. Statistical data analysis was performed by using the programme Statistica.

Results: 83% of the children enrolled in the programme were regarded as ‘high risk’ patient, 15% as ‘moderate risk’ and only 2% as ‘low risk’ patient. The mean DMFT score of all study participants was 1,84 and the def-t score was 2,39. 20% of the patients were caries free. The overall SiC Index was 8,82. The data obtained revealed a significant correlation between caries and frequent sugar consummation, visible plaque accumulation, lack of dental home and high caries prevalence in the family.

Discussion: The caries prevalence in children in Budapest declines but still exceeds the WHO recommendations. Therefore, the authors emphasize the importance of caries risk assessment as a prerequisite for appropriate preventive and treatment intervention decisions.

Speaker
Biography:

Wiem Bouaziz-Zouaoui works at Periosystem in France. Her research interests are Periodontology, Oral & Maxillofacial surgery.

Abstract:

Dentistry and specifically Periodontology is certainly one of the specialties that have been able to take advantage of new technologies and the digital revolution to support the field of scientific and medical research of which it is a major contributor. With this in mind, I tried to take advantage of the IT revolution by creating the computer tool PERIOSYSTEM. It brings together the revolutionary solutions in computer science, clinical research in Periodontology to facilitate its progress. Indeed, one of the major difficulties of clinical research (including large sample studies) is the time required for data collection, sorting and reporting in a statistically exploitable format, the risk of errors due to re-transcription.

Speaker
Biography:

Aldo Ivan Guzman de Hoyos is from Monclova, Coahuila México, he has completed at the age of 21 years old from Universidad Autónoma de Nuevo León, his dentistry studies, and at the 24 years old from Coahuila Unidad Torreón his Master in Paediatric Dentistry. He is research teacher in AME University in Monterrey Nuevo León, México and has published 10 papers in reputed journals, is Scientific Commission in the Academia Mexicana de Odontología Pediátrica since 2014.

Abstract:

World preventive dentistry has changed its approach, the emergence of new angles with respect to the etiology of the carious process as well as its dynamism has promoted that simply the effectiveness of treatments has been increasing thus improving the prevention schemes and individualizing them generating a more specific preventive dentistry. Studies show that Fluoride by itself, the inclusion of calcium in the chlorhexidine, the toothpaste, none can be effective by itself if not analyzed each case in an integral way every day is recommended more the use of products that generate an ion exchange between the biofilm and the dental materials causing a beneficial interaction for the host, likewise we enter the era of bacterial disruption and recolonization to promote a better biofilm that is compatible with the oral life of our patient

The recolonization of Biofilm is carried out based on oral probiotics, we know that probiotics are “living microorganisms which when administered in an adequate amount provide a benefit to the host”, there are probiotics that are most suitable for the oral cavity and they are the basis for current prevention and the integral approach to which we refer.

Speaker
Biography:

Cleverton Corrêa Rabelo has completed his Ph.D. in Periodontology in 2015 at the Guarulhos University, São Paulo, Brazil. He is currently studying postdoctoral. He has developed research in the area of periodontics and patients with special needs.

Abstract:

The peri-implant diseases bear great resemblance to periodontal diseases, from anatomopathological features, microbiological profiles, and immunological susceptibility to the forms of treatment. Despite the rational sharing of therapeutic bases, the effectiveness of procedures for decontamination of implant surfaces is considered a critical factor for the success of peri-implant disease therapy. Both the spiral-shaped macrostructure and the irregular microstructure of the titanium surface, promoted by the surface-blasting treatments, make the implant more favorable to adhesion and retention of plaque when exposed. Root scaling and straightening (RAR), considered gold standard due to its predictability in the resolution of periodontal disease, has limited efficacy in the treatment of peri-implant disease when bacterial biofilms reach the implants’ spines. Different methods have been proposed to support RAR in order to eliminate bacterial colonies on the titanium surface, helping to eliminate the peri-implant pocket. Detoxification by high-resolution laser has been used in the treatment of peri-implantitis with promising results in the decontamination of the implant surface, as well as aiding the inflammatory response through biomodulating action. The interaction of the laser with the peri-implant surface results in the removal of possible bacterial calcified deposits besides allowing re-osseointegration in regenerative therapy. Laser-assisted regenerative or anti-inflammatory therapies have shown better results in the treatment of peri-implantitis compared to RAR alone and further studies are needed to confirm the scientific evidence.

Aye Myat Thwe

University of Dundee, United Kingdom

Title: Role of EGFR inhibitors in oral cancer cell migration
Speaker
Biography:

Aye Thwe graduated from Myanmar with a Bachelor of Dental Surgery in 2010. After practicing as a Dentist for 2 years, she came to UK to study at University of Dundee. She received an MRes in Oral Cancer and progressed into the PhD programme. She is now in the 3rd year of her PhD programme.

Abstract:

Epithelial to mesenchymal transition (EMT) is the process by which cells change shape from being tightly connected epithelial cells to a more motile mesenchymal cell. EMT has been reported to facilitate cell migration. Cell motility is an initial first step on the road to metastasis. Epidermal growth factor receptor (EGFR) has been reported to be overexpressed in oral cancer and is often related to poor prognosis. Epidermal growth factor (EGF) and transforming growth factor (TGFα) are ligands that bind to EGFR and can affect many different cellular processes such as proliferation, migration, apoptosis etc. In this project, cell proliferation, migration, morphology change and EMT makers of HSG, AZA1, HacaT, and TYS are measured by cell counting, scratch assay, photographic image capturing and immunofluorescence in related with addition of 1 ng/ ml, 10 ng/ml, 50 ng/ml of EGF and TGFα incubated at different time point. 10 ng/ml and 50 ng/ml concentration induce morphology change (EMT like phenotype with finger-like projection) and increase migration while there is not much difference in cell proliferation. Their morphological changes are completely blocked by 1hour pre-treatment with 5μM Gefitinib (EGFR tyrosine kinase inhibitor), 5 μM Erlotinib (EGFR TK inhibitor) and 25 μM PD (MAPK inhibitor) while there is no blockage of cell migration.

Speaker
Biography:

Sultan Qead AlHobail has completed his MSc from Riyadh Elm University and did his BDS studiesfrom Riyadh Colleges of Dentistry and Pharmacy. He has published four papers in reputed Dental journals and has been member in different association such as IADR & Saudi Dental Association.

Abstract:

In spite of the recent improvement in awareness about oral and dental health among the public; dental caries remains a significant problem especially in developing countries. Since Saudi Arabia is a large, multicultural country; caries prevalence varies in its different regions and cities. However, caries prevalence is high in most regions and cities of Saudi Arabia. Caries is a biofilm (plaque)-induced acid demineralization of enamel or dentin, mediated by saliva. For the disease of early childhood caries (ECC) is the presence of 1 or more decayed (noncavitated or cavitated lesions), missing (due to caries), or filled tooth surfaces in any primary tooth in a child 71 months of age or younger. For Saudi Arabia’s Vision 2030 to prolonging life by preventing caries & Promoting the quality of KSA preventive and therapeutic Dental Health Care Services. The public sector will focus on promoting preventive care, on reducing dental infectious diseases and in encouraging citizens to make use of primary dental care as a first step. It will deepen collaboration and integration between health and social care, as well as supporting families to provide dental home care when necessary for their relatives.