Day 2 :
Keynote Forum
Kamran Awan
Roseman University, USA
Keynote: Human papillomavirus (HPV) involvement in the carcinogenesis of oropharyngeal cancer
Biography:
Kamran Habib Awan is a renowned international speaker in the field of oral medicine and diagnosis. He completed his bachelor’s in dental surgery with first division from Karachi University in 1997. Dr. Awan was awarded his Ph.D. in oral medicine from Kings College, London in 2011. His study was the first ever to evaluate the number of diagnostic methods in comparison to surgical biopsy (gold standard). He serves as an advisory board member for several reputed journals. He also has numerous publications to his name. His research interests include oral cancer and diagnosis. Dr. Awan currently serves as an associate professor at the Roseman University of Health Sciences, Utah, United States.
Abstract:
Human papillomavirus (HPV) has for some time been suggested to be involved in the carcinogenesis of oropharyngeal cancer. The HPV is a small, circular double-stranded DNA virus that was first identified in 1949. Up till now, over 100 different HPV types have been identified. The HPV subtypes are divided into high-risk and low-risk HPV based on their malignant potential. Approximately, 15 high-risk subtypes are known but only HPV subtypes 16, 18, 31, 33, and 35 have been identified playing a role in the development of oropharyngeal head and neck cancer. The HPV 16 is the most common type detected in oropharyngeal cancer accounting for 90 to 95% of the HPV-positive tumors. The International Agency for Research on Cancer (IARC) now recognizes HPV as a risk factor for oropharyngeal cancer and accumulating molecular and epidemiological data now show that high-risk types of HPV are responsible for a subset of oropharyngeal cancer. Majority of the HPV-positive oropharyngeal cancers lack association with the traditional risk factors, such as tobacco and alcohol. Alike HPV-associated cervical cancers, HPV-positive oropharyngeal cancers are also sexually transmitted. It is assumed that HPV infection precedes the development of HPV-positive head and neck cancers, and the presence of high-risk HPV infection on the oral mucosa and seropositivity increases the risk of development of head and neck cancers. Therefore, risk factors for oral HPV infection are likely to be risk factors for HPV-positive head and neck cancers.
Keynote Forum
Kariem M Elhelow
King Abdullah Medical City, Saudi Arabia
Keynote: Dental implants in pediatric jaws. Any new solutions for old problems?
Biography:
Kariem M Elhelow BDS, MS, Ph.D., is working a Consultant of Implant and Maxillofacial Prosthodontics, in King Abdullah Medical City, Makkah, Saudi Arabia. He worked as a prosthodontist in Alexandria University as well as Salametek Dental Centers. Dr. Elhelow received his BDS, and MS from Alexandria University, and his Ph.D. from Cairo University, Egypt. He is also a fellow of the ICOI. He is an author and international public speaker lecturing on implant, maxillofacial prosthodontics, and digital dentistry.
Abstract:
Traumatic tooth loss is a common incident in active children. The mean prevalence of congenitally missing teeth was reported to be 6.53% ± 3.33%; and therefore, they make up the vastness of the developmental anomaly of the human dentition. While researches are extensively addressing every aspect related to implants in adults, a paucity of equivalent articles are tackling dental implants in growing children and adolescents. It is widely accepted that dental implants should not be installed in growing children. The presentation will elaborate on how far this notion holds true today together with the clinical encounters anticipated. Knowledge about the behavior of dental implants in growing jaws coupled with correct patient selection and clinical guidelines are paving the way to more predictable functional and esthetic outcomes. The purpose of this article is to draw a roadmap to decision making addressing the do’s and don’ts when considering dental implants in growing children.
Conclusion: Implant rehabilitation is possible in young jaws. Growth assessment together with multidisciplinary management is crucial to avoid functional and esthetic failures.
Recommendations: Aside from the points highlighted in the presentation, it is recommended that Implant practitioners become oriented with growth assessment methods; a skill that is frequently overlooked.
Keynote Forum
Kariem M Elhelow
King Abdullah Medical City, Saudi Arabia
Keynote: Dental implants in pediatric jaws. Any new solutions for old problems?
Time : 11:00-11:45
Biography:
Kariem M Elhelow BDS, MS, Ph.D., is working a Consultant of Implant and Maxillofacial Prosthodontics, in King Abdullah Medical City, Makkah, Saudi Arabia. He worked as a prosthodontist in Alexandria University as well as Salametek Dental Centers. Dr. Elhelow received his BDS, and MS from Alexandria University, and his Ph.D. from Cairo University, Egypt. He is also a fellow of the ICOI. He is an author and international public speaker lecturing on implant, maxillofacial prosthodontics, and digital dentistry.
Abstract:
Traumatic tooth loss is a common incident in active children. The mean prevalence of congenitally missing teeth was reported to be 6.53% ± 3.33%; and therefore, they make up the vastness of the developmental anomaly of the human dentition. While researches are extensively addressing every aspect related to implants in adults, a paucity of equivalent articles are tackling dental implants in growing children and adolescents. It is widely accepted that dental implants should not be installed in growing children. The presentation will elaborate on how far this notion holds true today together with the clinical encounters anticipated. Knowledge about the behavior of dental implants in growing jaws coupled with correct patient selection and clinical guidelines are paving the way to more predictable functional and esthetic outcomes. The purpose of this article is to draw a roadmap to decision making addressing the do’s and don’ts when considering dental implants in growing children.
Conclusion: Implant rehabilitation is possible in young jaws. Growth assessment together with multidisciplinary management is crucial to avoid functional and esthetic failures.
Recommendations: Aside from the points highlighted in the presentation, it is recommended that Implant practitioners become oriented with growth assessment methods; a skill that is frequently overlooked.
- Periodontics and Oral Hygiene | Restorative Dentistry and Endodontic | Cosmetic Dentistry | Oral Oncology | Dental Public Health | Radiology
Location: International A
Chair
Jason Post
MBS Secure, USA
Co-Chair
Kamran Awan
Roseman University, USA
Session Introduction
Dora Zs Nagy
Semmelweis University, Hungary
Title: Caries risk assessment in children between 6-18 in Budapest, Hungary
Biography:
Dora Zsofia Nagy graduated from Semmelweis University, Budapest, Hungary in 2014. Since then she has been working at the Department of Paediatric Dentistry and Orthodontics at Semmelweis University. She is a specialist in paediatric dentistry and currently enrolled in the orthodontic residency programme. Besides the daily clinical practice, she has been involved in scientific research projects at the department and in the training of undergraduate students in the Hungarian, English and German speaking dentistry programmes.
Abstract:
Materials and Methods: Dental caries has been a major public health problem for many years in Hungary and still continues to be, affecting in many ways normal growth and development as well as social adaptation of children. A research on caries risk assessment was conducted at the Department of Paediatric Dentistry and Orthodontics at Semmelweis University with 116 children aged 6-18 (mean age: 10, 4). Based on the clinical dental status evaluation the prevalence of dental caries, DMFT, def-t, DF/df-T/t score, and Significant Caries Index (SiC) were calculated. For caries risk assessment the questionnaire of the American Dental Association was filled in by the patients’ caretaker. Statistical data analysis was performed by using the programme Statistica.
Results: 83% of the children enrolled in the programme were regarded as ‘high risk’ patient, 15% as ‘moderate risk’ and only 2% as ‘low risk’ patient. The mean DMFT score of all study participants was 1,84 and the def-t score was 2,39. 20% of the patients were caries free. The overall SiC Index was 8,82. The data obtained revealed a significant correlation between caries and frequent sugar consummation, visible plaque accumulation, lack of dental home and high caries prevalence in the family.
Discussion: The caries prevalence in children in Budapest declines but still exceeds the WHO recommendations. Therefore, the authors emphasize the importance of caries risk assessment as a prerequisite for appropriate preventive and treatment intervention decisions.
Biography:
Abstract:
Dentistry and specifically Periodontology is certainly one of the specialties that have been able to take advantage of new technologies and the digital revolution to support the field of scientific and medical research of which it is a major contributor. With this in mind, I tried to take advantage of the IT revolution by creating the computer tool PERIOSYSTEM. It brings together the revolutionary solutions in computer science, clinical research in Periodontology to facilitate its progress. Indeed, one of the major difficulties of clinical research (including large sample studies) is the time required for data collection, sorting and reporting in a statistically exploitable format, the risk of errors due to re-transcription.
Aldo Ivan Guzman de Hoyos
OdontologÃa Infantil Monclova, Mexico
Title: Preventive Dentistry in Pediatric Dentistry a new perspective based on recolonization
Biography:
Aldo Ivan Guzman de Hoyos is from Monclova, Coahuila México, he has completed at the age of 21 years old from Universidad Autónoma de Nuevo León, his dentistry studies, and at the 24 years old from Coahuila Unidad Torreón his Master in Paediatric Dentistry. He is research teacher in AME University in Monterrey Nuevo León, México and has published 10 papers in reputed journals, is Scientific Commission in the Academia Mexicana de Odontología Pediátrica since 2014.
Abstract:
World preventive dentistry has changed its approach, the emergence of new angles with respect to the etiology of the carious process as well as its dynamism has promoted that simply the effectiveness of treatments has been increasing thus improving the prevention schemes and individualizing them generating a more specific preventive dentistry. Studies show that Fluoride by itself, the inclusion of calcium in the chlorhexidine, the toothpaste, none can be effective by itself if not analyzed each case in an integral way every day is recommended more the use of products that generate an ion exchange between the biofilm and the dental materials causing a beneficial interaction for the host, likewise we enter the era of bacterial disruption and recolonization to promote a better biofilm that is compatible with the oral life of our patient
The recolonization of Biofilm is carried out based on oral probiotics, we know that probiotics are “living microorganisms which when administered in an adequate amount provide a benefit to the host”, there are probiotics that are most suitable for the oral cavity and they are the basis for current prevention and the integral approach to which we refer.
Cleverton Corrêa Rabelo
Federal University of Juiz de Fora, Brazil
Title: Laser as an adjunct in the treatment of peri-implantitis
Biography:
Cleverton Corrêa Rabelo has completed his Ph.D. in Periodontology in 2015 at the Guarulhos University, São Paulo, Brazil. He is currently studying postdoctoral. He has developed research in the area of periodontics and patients with special needs.
Abstract:
The peri-implant diseases bear great resemblance to periodontal diseases, from anatomopathological features, microbiological profiles, and immunological susceptibility to the forms of treatment. Despite the rational sharing of therapeutic bases, the effectiveness of procedures for decontamination of implant surfaces is considered a critical factor for the success of peri-implant disease therapy. Both the spiral-shaped macrostructure and the irregular microstructure of the titanium surface, promoted by the surface-blasting treatments, make the implant more favorable to adhesion and retention of plaque when exposed. Root scaling and straightening (RAR), considered gold standard due to its predictability in the resolution of periodontal disease, has limited efficacy in the treatment of peri-implant disease when bacterial biofilms reach the implants’ spines. Different methods have been proposed to support RAR in order to eliminate bacterial colonies on the titanium surface, helping to eliminate the peri-implant pocket. Detoxification by high-resolution laser has been used in the treatment of peri-implantitis with promising results in the decontamination of the implant surface, as well as aiding the inflammatory response through biomodulating action. The interaction of the laser with the peri-implant surface results in the removal of possible bacterial calcified deposits besides allowing re-osseointegration in regenerative therapy. Laser-assisted regenerative or anti-inflammatory therapies have shown better results in the treatment of peri-implantitis compared to RAR alone and further studies are needed to confirm the scientific evidence.
Aye Myat Thwe
University of Dundee, United Kingdom
Title: Role of EGFR inhibitors in oral cancer cell migration
Biography:
Aye Thwe graduated from Myanmar with a Bachelor of Dental Surgery in 2010. After practicing as a Dentist for 2 years, she came to UK to study at University of Dundee. She received an MRes in Oral Cancer and progressed into the PhD programme. She is now in the 3rd year of her PhD programme.
Abstract:
Epithelial to mesenchymal transition (EMT) is the process by which cells change shape from being tightly connected epithelial cells to a more motile mesenchymal cell. EMT has been reported to facilitate cell migration. Cell motility is an initial first step on the road to metastasis. Epidermal growth factor receptor (EGFR) has been reported to be overexpressed in oral cancer and is often related to poor prognosis. Epidermal growth factor (EGF) and transforming growth factor (TGFα) are ligands that bind to EGFR and can affect many different cellular processes such as proliferation, migration, apoptosis etc. In this project, cell proliferation, migration, morphology change and EMT makers of HSG, AZA1, HacaT, and TYS are measured by cell counting, scratch assay, photographic image capturing and immunofluorescence in related with addition of 1 ng/ ml, 10 ng/ml, 50 ng/ml of EGF and TGFα incubated at different time point. 10 ng/ml and 50 ng/ml concentration induce morphology change (EMT like phenotype with finger-like projection) and increase migration while there is not much difference in cell proliferation. Their morphological changes are completely blocked by 1hour pre-treatment with 5μM Gefitinib (EGFR tyrosine kinase inhibitor), 5 μM Erlotinib (EGFR TK inhibitor) and 25 μM PD (MAPK inhibitor) while there is no blockage of cell migration.
Sultan Qead AlHobail
Riyadh Elm University, Saurdi Arabia
Title: Advanced treatment for ECC in KSA region for a better dental public health care 2030 vision
Biography:
Sultan Qead AlHobail has completed his MSc from Riyadh Elm University and did his BDS studiesfrom Riyadh Colleges of Dentistry and Pharmacy. He has published four papers in reputed Dental journals and has been member in different association such as IADR & Saudi Dental Association.
Abstract:
In spite of the recent improvement in awareness about oral and dental health among the public; dental caries remains a significant problem especially in developing countries. Since Saudi Arabia is a large, multicultural country; caries prevalence varies in its different regions and cities. However, caries prevalence is high in most regions and cities of Saudi Arabia. Caries is a biofilm (plaque)-induced acid demineralization of enamel or dentin, mediated by saliva. For the disease of early childhood caries (ECC) is the presence of 1 or more decayed (noncavitated or cavitated lesions), missing (due to caries), or filled tooth surfaces in any primary tooth in a child 71 months of age or younger. For Saudi Arabia’s Vision 2030 to prolonging life by preventing caries & Promoting the quality of KSA preventive and therapeutic Dental Health Care Services. The public sector will focus on promoting preventive care, on reducing dental infectious diseases and in encouraging citizens to make use of primary dental care as a first step. It will deepen collaboration and integration between health and social care, as well as supporting families to provide dental home care when necessary for their relatives.